Preheat oven to 350°. In a 10-in. cast-iron, cook beef over medium heat until no longer pink, 6-8 minutes, breaking into crumbles; drain.
Transfer to a small bowl. Stir in beans, salsa and taco seasoning; keep warm. Wipe skillet clean, and spray with no stick cooking spray.
Prepare cornbread mix according to package directions; stir in crushed tortilla chips. Pour into skillet. Bake until set, 12-15 minutes.
Spread ground beef mixture over cornbread to within 1 in. of edges; sprinkle with cheese. Bake until cheese is melted and crust is golden brown, 3-5 minutes.
Top with the variations of toppings your family likes.